BDBM444926 6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-4-::US10668067, Example 1-87

SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1

InChI Key InChIKey=GOQUVLJOFUKMGN-UHFFFAOYSA-N

Data  7 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 444926   

LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 14nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Mouse)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of mouse Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human Nav1.5 at -50 mV holding potential by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed