BDBM444912 6-((4'-chloro-3-methoxy-3'-methyl-4-::US10668067, Example 1-73

SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1ccc(cc1OC)-c1ccc(Cl)c(C)c1

InChI Key InChIKey=LPSTUIKKMUOIOD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 444912   

LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 65nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
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TargetCytochrome P450 2C9(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Moma Therapeutics

Curated by ChEMBL
LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 5.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM444912(US10668067, Example 1-73 | 6-((4'-chloro-3-methoxy...)
Affinity DataIC50: 87nMAssay Description:Inhibition of human Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed