BDBM444541 US10662186, Compound 61::US10988476, Compound I-61

SMILES CN(C)CCN(C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1

InChI Key InChIKey=IVKYJVDFJKEXIH-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 444541   

TargetCyclin-dependent kinase 4(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 1.12nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 2.55nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 364nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 1(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 348nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 710nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 61.5nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 1.12nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 2.55nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 364nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 1(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 348nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 710nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM444541(US10662186, Compound 61 | US10988476, Compound I-6...)
Affinity DataIC50: 61.5nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent