BDBM444513 (R)-5-chloro-2-fluoro-4-(1-(3- methylbenzyl)pyrrolidin-3-ylamino)-N-(thiazol- 2-yl)benzenesulfonamide::US10662184, Example 88

SMILES Cc1cccc(c1)N1CC[C@@H](C1)Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1

InChI Key InChIKey=LSKHZCVLYTUIQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444513   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444513(US10662184, Example 88 | (R)-5-chloro-2-fluoro-4-(...)
Affinity DataIC50: 39nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444513(US10662184, Example 88 | (R)-5-chloro-2-fluoro-4-(...)
Affinity DataIC50: 1.25E+3nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent