BDBM444511 (S)-3-chloro-4-(methyl(1-(3- methylbenzyl)pyrrolidin-3-yl)amino)-N-(1,2,4- thiadiazol-5-yl)benzenesulfonamide::US10662184, Example 83

SMILES Cc1cccc(CN2CC[C@@H](C2)Nc2ccc(cc2Cl)S(=O)(=O)Nc2ncns2)c1

InChI Key InChIKey=MVUZMVLLJHYYJQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444511   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444511(US10662184, Example 83 | (S)-3-chloro-4-(methyl(1-...)
Affinity DataIC50: 36nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM444511(US10662184, Example 83 | (S)-3-chloro-4-(methyl(1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent