BDBM443440 US10654866, Example 7::US11634426, Example 7

SMILES Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1

InChI Key InChIKey=DRPASBVXQUEVRW-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 443440   

TargetEstrogen receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM443440(US10654866, Example 7 | US11634426, Example 7)
Affinity DataKi:  1.55nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM443440(US10654866, Example 7 | US11634426, Example 7)
Affinity DataKi:  1.55nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443440(US10654866, Example 7 | US11634426, Example 7)
Affinity DataKi:  8.55nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443440(US10654866, Example 7 | US11634426, Example 7)
Affinity DataKi:  8.55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent