BDBM443429 US10654866, Example 1A::US11117902, Example 1B::US11634426, Example 1A

SMILES Oc1ccc2c3[C@H](Oc4cc(ccc4-c3cnc2c1)C(F)(F)F)c1ccc(OCCN2CC(CF)C2)cc1

InChI Key InChIKey=UVBQMXOKKDCBJN-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 443429   

TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataIC50: 3nMAssay Description:Induction of wild type ERalpha degradation in human MCF cells by high content imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataIC50: 9.60nMAssay Description:Induction of ERalpha Y537N mutant degradation in human MCF cells high content imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  0.310nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity to wild type ERalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  2.79nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  12.4nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  12.4nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  57.2nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  57.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent