BDBM443394 (S)-1-(4,5-dihydro-21-benzo[e]indazol-7-yl)-3-((3-methoxyphenyl)amino)pyrolidin-2-one::US10654860, Example 3

SMILES COc1cccc(N[C@H]2CCN(C2=O)c2ccc3-c4c[nH]nc4CCc3c2)c1

InChI Key InChIKey=OZAJGSRJLGVNSW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 443394   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443394(US10654860, Example 3 | (S)-1-(4,5-dihydro-21-benz...)
Affinity DataIC50: 10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent