BDBM443393 1-(4,5-dihydro-2H-benzo[e]indazol-7-yl)-3-(3-methoxybenzyl)imidazolidin-2-one::US10654860, Example 2

SMILES COc1cccc(CN2CCN(C2=O)c2ccc3-c4c[nH]nc4CCc3c2)c1

InChI Key InChIKey=RVWQJPOZGRDNEI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 443393   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443393(US10654860, Example 2 | 1-(4,5-dihydro-2H-benzo[e]...)
Affinity DataIC50: 10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443393(US10654860, Example 2 | 1-(4,5-dihydro-2H-benzo[e]...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed