BDBM443392 (rac)-1''-(4,5-dihydro-2H-benzo[e]indazol-7-yl)spiro[indoline-2,3''-pyrrolidin]-2''-one::US10654860, Example 1::US10654860, Example 16::US10654860, Example 6

SMILES O=C1N(CCC11Cc2ccccc2N1)c1ccc2-c3c[nH]nc3CCc2c1

InChI Key InChIKey=KXLZFLROANWIKV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 443392   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443392(US10654860, Example 16 | (rac)-1''-(4,5-dihydro-2H...)
Affinity DataIC50: 10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443392(US10654860, Example 16 | (rac)-1''-(4,5-dihydro-2H...)
Affinity DataIC50: 10nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM443392(US10654860, Example 16 | (rac)-1''-(4,5-dihydro-2H...)
Affinity DataIC50: 55nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent