BDBM443385 ALTERNATIVE ROUTE 1: (S)-4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE::US10654855, Example 9::US11236095, Example 9

SMILES c1cc(ccc1[C@H](CCO)NC(=O)C2(CCN(CC2)c3c4cc[nH]c4ncn3)N)Cl

InChI Key InChIKey=JDUBGYFRJFOXQC-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 443385   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM443385(US10654855, Example 9 | ALTERNATIVE ROUTE 1: (S)-4...)
Affinity DataIC50: 3.20nMAssay Description:For Echo dosing the solvent was 100% DMSO. A master plate was prepared with 40 ul of 10 mM stock from our Primary Liquid Store in quadrant 1 of a Lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM443385(US10654855, Example 9 | ALTERNATIVE ROUTE 1: (S)-4...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM443385(US10654855, Example 9 | ALTERNATIVE ROUTE 1: (S)-4...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Akt-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-beta serine/threonine-protein kinase(Human)
University of Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM443385(US10654855, Example 9 | ALTERNATIVE ROUTE 1: (S)-4...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Akt-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-gamma serine/threonine-protein kinase(Human)
University of Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM443385(US10654855, Example 9 | ALTERNATIVE ROUTE 1: (S)-4...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Akt-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM443385(US10654855, Example 9 | ALTERNATIVE ROUTE 1: (S)-4...)
Affinity DataIC50: 3.20nMAssay Description:Following addition of compound or control to the assay plate, 6p1 peptide mix containing 3 μM substrate (5-FAM-GRPRTSSFAEG-CONH2; CRB) and 40 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM443385(US10654855, Example 9 | ALTERNATIVE ROUTE 1: (S)-4...)
Affinity DataIC50: 8nMAssay Description:Inhibition of AKT1 (unknown origin) incubated for 40 mins in presence of ATP by Kinase-Glo reagent based luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)