BDBM443227 N-(5-(4-Cyclopropylpiperazin-1-yl)-2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)phenyl) acrylamide::US10654836, Example 8::US11001572, Example 8

SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C3CC3)ncn2)c1Cl

InChI Key InChIKey=GTRUQMSGMBIRPQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 443227   

TargetFibroblast growth factor receptor 1(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 618nMAssay Description:The experimental procedure is briefly described as follows: the test compound was first dissolved in DMSO to prepare a stock solution, and then gradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 644nMAssay Description:The experimental procedure is briefly described as follows: the test compound was first dissolved in DMSO to prepare a stock solution, and then gradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 880nMAssay Description:The experimental procedure is briefly described as follows: the test compound was first dissolved in DMSO to prepare a stock solution, and then gradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 2.5nMAssay Description:The experimental procedure is briefly described as follows: the test compound was first dissolved in DMSO to prepare a stock solution, and then gradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 618nMAssay Description:The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 644nMAssay Description:The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 880nMAssay Description:The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM443227(US10654836, Example 8 | N-(5-(4-Cyclopropylpiperaz...)
Affinity DataIC50: 2.5nMAssay Description:The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent