BDBM443121 US10654831, Compound 46

SMILES CC(C)[C@H]1CNC(=O)N1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1

InChI Key InChIKey=KFWWADMEKVSFFA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 443121   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443121(US10654831, Compound 46)
Affinity DataIC50: 761nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443121(US10654831, Compound 46)
Affinity DataIC50: 3.30E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443121(US10654831, Compound 46)
Affinity DataIC50: 2.30E+4nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443121(US10654831, Compound 46)
Affinity DataIC50: 9.70E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent