BDBM443120 US10654831, Compound 40

SMILES C[C@H]1CNC(=O)CN1c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1

InChI Key InChIKey=YEWXJCQRVAYQMR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 443120   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443120(US10654831, Compound 40)
Affinity DataIC50: 1.70E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443120(US10654831, Compound 40)
Affinity DataIC50: 5.70E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443120(US10654831, Compound 40)
Affinity DataIC50: 7.10E+4nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM443120(US10654831, Compound 40)
Affinity DataIC50: 8.80E+4nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays to determine their inhibitory effect on th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent