BDBM4431 (4S,5S)-2,7-bis({[2-(4-fluorophenyl)phenyl]methyl})-4,5-dihydroxy-1,2,7-thiadiazepane-1,1-dione::cyclic sulfamide, biphenyl analog 18

SMILES O[C@H]1CN(Cc2ccccc2-c2ccc(F)cc2)S(=O)(=O)N(Cc2ccccc2-c2ccc(F)cc2)C[C@@H]1O

InChI Key InChIKey=HTRNCVRVWDPENT-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4431   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

LigandPNGBDBM4431((4S,5S)-2,7-bis({[2-(4-fluorophenyl)phenyl]methyl}...)
Affinity DataKi:  5.30E+3nM ΔG°:  -7.31kcal/molepH: 5.0 T: 2°CAssay Description:The effects of the inhibitors on the activity of HIV-1 proteinase was determined by a fluorometric assay with an internally quenched fluorescent pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed