BDBM442768 1,6-Dimethyl-N- {1-[4-(trifluoro- methyl)phenyl]- cyclobutyl}-1H- pyrazolo[3,4-d]- pyrimidin-4-amine::US10647727, Example 25

SMILES Cc1nc(NC2(CCC2)c2ccc(cc2)C(F)(F)F)c2cnn(C)c2n1

InChI Key InChIKey=ZLGZMDIZQFJTID-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442768   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442768(US10647727, Example 25 | 1,6-Dimethyl-N- {1-[4-(tr...)
Affinity DataKi:  358nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442768(US10647727, Example 25 | 1,6-Dimethyl-N- {1-[4-(tr...)
Affinity DataKi:  430nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent