BDBM442766 1,6-Dimethyl-N- (1-{4- [(trifluoromethyl)- sulfanyl]phenyl}- cyclopropyl)-1H- pyrazolo[3,4-d]- pyrimidin-4-amine::US10647727, Example 23

SMILES Cc1nc(NC2(CC2)c2ccc(SC(F)(F)F)cc2)c2cnn(C)c2n1

InChI Key InChIKey=TZIIVJMNZFTMKG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442766   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442766(US10647727, Example 23 | 1,6-Dimethyl-N- (1-{4- [(...)
Affinity DataKi:  16nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442766(US10647727, Example 23 | 1,6-Dimethyl-N- (1-{4- [(...)
Affinity DataKi:  20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent