BDBM442763 1,6-Dimethyl- N-{(1R)-1-[4- (trifluoromethyl)- phenyl]ethyl}-1H- pyrazolo[3,4-d]- pyrimidin-4-amine::US10647727, Example 21

SMILES C[C@@H](Nc1nc(C)nc2n(C)ncc12)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=XNZPHWRUVQOXID-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442763   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442763(US10647727, Example 21 | 1,6-Dimethyl- N-{(1R)-1-[...)
Affinity DataKi:  140nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442763(US10647727, Example 21 | 1,6-Dimethyl- N-{(1R)-1-[...)
Affinity DataKi:  194nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent