BDBM442759 6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phenyl]cyclopropyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine::US10647727, Example 17

SMILES CN(c1nc(Cl)nc2n(C)ncc12)C1(CC1)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=AIHKYHHHMRTKDI-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 442759   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442759(US10647727, Example 17 | 6-Chloro-N,1-dimethyl-N-{...)
Affinity DataKi:  1.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442759(US10647727, Example 17 | 6-Chloro-N,1-dimethyl-N-{...)
Affinity DataKi:  3.80nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442759(US10647727, Example 17 | 6-Chloro-N,1-dimethyl-N-{...)
Affinity DataKi:  6nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent