BDBM442104 US10647713, Compound I-46::US11396508, Compound I-46

SMILES COc1c(Nc2cc(Nc3ccc(NCCCCl)c(n3)C#N)nc3[nH]c(nc23)C(F)F)cccc1-c1nnn(C)n1

InChI Key InChIKey=BGPUTAKCYHUOSU-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442104   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM442104(US10647713, Compound I-46 | US11396508, Compound I...)
Affinity DataKd:  0.75nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM442104(US10647713, Compound I-46 | US11396508, Compound I...)
Affinity DataKd:  2.50E+5nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent