BDBM441843 US10647665, Example 1-29::US10851050, Example I-29

SMILES OC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)nc1

InChI Key InChIKey=FGMLEAPNNGWQGI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 441843   

TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441843(US10647665, Example 1-29 | US10851050, Example I-2...)
Affinity DataIC50: 500nMAssay Description:1. Preparation of RORgamma Buffer Solution10 mL of DTT and 100 mL buffer solution were gently mixed together and ready to use.2. Preparation of Compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441843(US10647665, Example 1-29 | US10851050, Example I-2...)
Affinity DataIC50: 500nMAssay Description:The inhibitory activity of compounds on RORγ receptor was determined by fluorescence resonance energy transfer (FRET) experiments. The inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2021
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441843(US10647665, Example 1-29 | US10851050, Example I-2...)
Affinity DataIC50: 390nMAssay Description:Inverse agonist activity at human RORgammat assessed as inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed