BDBM441837 US10647665, Example 1-23::US10851050, Example I-23

SMILES OC(=O)Cc1ccc(CNC(=O)Nc2ccc(cc2)-c2ccccc2)cc1

InChI Key InChIKey=JGINBPKDFJSKCS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 441837   

TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441837(US10647665, Example 1-23 | US10851050, Example I-2...)
Affinity DataIC50: 2.75E+5nMAssay Description:1. Preparation of RORgamma Buffer Solution10 mL of DTT and 100 mL buffer solution were gently mixed together and ready to use.2. Preparation of Compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441837(US10647665, Example 1-23 | US10851050, Example I-2...)
Affinity DataIC50: 2.75E+4nMAssay Description:The inhibitory activity of compounds on RORγ receptor was determined by fluorescence resonance energy transfer (FRET) experiments. The inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2021
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441837(US10647665, Example 1-23 | US10851050, Example I-2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inverse agonist activity at human RORgammat assessed as inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed