BDBM441827 US10647665, Example 1-14::US10851050, Example I-14

SMILES OC(=O)c1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1

InChI Key InChIKey=OIYOCHFKDFUMFW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 441827   

TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441827(US10647665, Example 1-14 | US10851050, Example I-1...)
Affinity DataIC50: 2.75E+3nMAssay Description:1. Preparation of RORgamma Buffer Solution10 mL of DTT and 100 mL buffer solution were gently mixed together and ready to use.2. Preparation of Compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441827(US10647665, Example 1-14 | US10851050, Example I-1...)
Affinity DataIC50: 2.75E+3nMAssay Description:The inhibitory activity of compounds on RORγ receptor was determined by fluorescence resonance energy transfer (FRET) experiments. The inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2021
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Fudan University

US Patent
LigandPNGBDBM441827(US10647665, Example 1-14 | US10851050, Example I-1...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inverse agonist activity at human RORgammat assessed as inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed