BDBM441065 US10640495, Example I-211::US10640495, Example I-57

SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(OC)nc2)[C@@H](O1)c1cnc(F)c(F)c1

InChI Key InChIKey=PCQXASNGMDRXHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 441065   

TargetHigh affinity nerve growth factor receptor(Human)
Shionogi

US Patent
LigandPNGBDBM441065(US10640495, Example I-211 | US10640495, Example I-...)
Affinity DataIC50: 2.20nMAssay Description:Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Shionogi

US Patent
LigandPNGBDBM441065(US10640495, Example I-211 | US10640495, Example I-...)
Affinity DataIC50: 1.5nMAssay Description:Seven point five μL per well of human TrkA (PV3144, Lifetechnologies, final concentration: 1 nmol/L) suspended in the assay buffer (100 mmol/L 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent