BDBM440444 US10633389, Example 109-3::US20230279020, Example 109-3

SMILES CNC[C@@H](O)COc1ccc(Cl)c(c1)-c1nc(N2CC3(C2)CCN(CC3)C(=O)OC)c(C)c(n1)-c1c(C)noc1C

InChI Key InChIKey=OWCOTUVKROVONT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 440444   

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween 20, prepared on the day of use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 6nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Epizyme

US Patent
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed