BDBM438725 21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(5,7)-pyrazolo[4,3-b]pyridina-1,5(3,2)- dipyridinacyclododecaphane::US10618913, Example 4

SMILES CC(C)n1nc(C)c2nc-3cc(NCc4cccnc4OCCOCCOc4ncccc-34)c12

InChI Key InChIKey=IFJHYKXAQOIJLS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 438725   

LigandPNGBDBM438725(21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
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LigandPNGBDBM438725(21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(...)
Affinity DataIC50: 0.540nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM438725(21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(...)
Affinity DataIC50: 16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent