BDBM438120 US10618886, Compound XIII::US10730853, Compound XIII::US11420955, Compound XIII

SMILES COc1cc(OCCCN2CCC[C@@H]2C)ccc1-n1c(C)nc2ccc(cc2c1=O)S(F)(F)(F)(F)F

InChI Key InChIKey=PDDJAOMUBIYZSN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 438120   

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438120(US10618886, Compound XIII | US10730853, Compound X...)
Affinity DataIC50: 5.63nMAssay Description:Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438120(US10618886, Compound XIII | US10730853, Compound X...)
Affinity DataIC50: 10.9nMAssay Description:Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438120(US10618886, Compound XIII | US10730853, Compound X...)
Affinity DataIC50: 5.63nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438120(US10618886, Compound XIII | US10730853, Compound X...)
Affinity DataIC50: 10.9nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438120(US10618886, Compound XIII | US10730853, Compound X...)
Affinity DataIC50: 5.63nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438120(US10618886, Compound XIII | US10730853, Compound X...)
Affinity DataIC50: 10.9nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent