BDBM438115 US10618886, Compound VIII::US10730853, Compound VIII::US11420955, Compound VIII

SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1O)S(F)(F)(F)(F)F

InChI Key InChIKey=UKTLRARTGHHSRA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 438115   

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438115(US10618886, Compound VIII | US10730853, Compound V...)
Affinity DataIC50: 6.11nMAssay Description:Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438115(US10618886, Compound VIII | US10730853, Compound V...)
Affinity DataIC50: 4.81nMAssay Description:Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438115(US10618886, Compound VIII | US10730853, Compound V...)
Affinity DataIC50: 6.11nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438115(US10618886, Compound VIII | US10730853, Compound V...)
Affinity DataIC50: 4.81nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438115(US10618886, Compound VIII | US10730853, Compound V...)
Affinity DataIC50: 6.11nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438115(US10618886, Compound VIII | US10730853, Compound V...)
Affinity DataIC50: 4.81nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent