BDBM438114 US10618886, Compound VII::US10730853, Compound VII::US11420955, Compound VII

SMILES CC1CCN(CCCOc2ccc(cc2)-n2c(C)nc3ccc(cc3c2=O)S(F)(F)(F)(F)F)C1

InChI Key InChIKey=GKIWHIYZAQPHFO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 438114   

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438114(US10618886, Compound VII | US10730853, Compound VI...)
Affinity DataIC50: 10.5nMAssay Description:Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438114(US10618886, Compound VII | US10730853, Compound VI...)
Affinity DataIC50: 3.44nMAssay Description:Briefly, for membrane parathion, HEK293/Ga15/hH3R cells were grown to confluence, harvested and the cell pellets were suspended in TEL buffer (50 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438114(US10618886, Compound VII | US10730853, Compound VI...)
Affinity DataIC50: 10.5nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438114(US10618886, Compound VII | US10730853, Compound VI...)
Affinity DataIC50: 3.44nMAssay Description:Materials: GTPγS, [35S] (PerkinElmer, Cat # NEG030H001MC), DMSO (Amresco, Cat #0231), MicroScint™-20 (PerkinElmer, Cat #6013621), CelLytic&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438114(US10618886, Compound VII | US10730853, Compound VI...)
Affinity DataIC50: 10.5nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetHistamine H3 receptor(Human)
Xw Laboratories

US Patent
LigandPNGBDBM438114(US10618886, Compound VII | US10730853, Compound VI...)
Affinity DataIC50: 3.44nMAssay Description:Experimental procedure: 1) Membrane preparation for HEK293/Ga15/hH3R; 2) Standard binding assay. Briefly, for membrane parathion, HEK293/Ga15/hH3R ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent