BDBM437843 US10596172, Compound I-177::US10828300, Compound I-177::US11351168, Compound I-177

SMILES COc1cccc(Nc2ncc(C(=O)NC3CC3)c(Oc3cccc(NC(=O)C=C)c3)n2)c1

InChI Key InChIKey=CJZJJZZZAOTWKI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 437843   

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM437843(US10596172, Compound I-177 | US10828300, Compound ...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM437843(US10596172, Compound I-177 | US10828300, Compound ...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM437843(US10596172, Compound I-177 | US10828300, Compound ...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM437843(US10596172, Compound I-177 | US10828300, Compound ...)
Affinity DataIC50: 55nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM437843(US10596172, Compound I-177 | US10828300, Compound ...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM437843(US10596172, Compound I-177 | US10828300, Compound ...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM437843(US10596172, Compound I-177 | US10828300, Compound ...)
Affinity DataIC50: 550nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent