BDBM437254 6-(2,4-Difluoro-3-methyl-phenyl)-1-[2-(3-fluoroazetidin-1-yl)-2-oxo-ethyl]-3- (fluoromethyl)imidazo[4,5-b]pyridin-2-one::US10617676, Example 600::US11207298, Example 600

SMILES Cc1c(F)ccc(-c2cnc3n(CF)c(=O)n(CC(=O)N4CC(F)C4)c3c2)c1F

InChI Key InChIKey=LORQXBLFVIKEBN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 437254   

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM437254(6-(2,4-Difluoro-3-methyl-phenyl)-1-[2-(3-fluoroaze...)
Affinity DataIC50: 17nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
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TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM437254(6-(2,4-Difluoro-3-methyl-phenyl)-1-[2-(3-fluoroaze...)
Affinity DataIC50: 17nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent