BDBM437079 1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]-6-(3,4-difluorophenyl)-3- methyl-imidazo[4,5-b]pyridin-2-one::US10617676, Example 416::US11207298, Example 416

SMILES Cn1c2ncc(cc2n(CC(=O)N2CC(F)(F)C2)c1=O)-c1ccc(F)c(F)c1

InChI Key InChIKey=NWSJEBMCYNVWKN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 437079   

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM437079(US10617676, Example 416 | 1-[2-(3,3-Difluoroazetid...)
Affinity DataIC50: 10nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM437079(US10617676, Example 416 | 1-[2-(3,3-Difluoroazetid...)
Affinity DataIC50: 10nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent