BDBM436958 6-(2,4-Difluoro-3-methyl-phenyl)-1-(3-pyridylmethyl)-3H-imidazo[4,5- b]pyridin-2-one::US10617676, Example 293::US11207298, Example 293

SMILES Cc1c(F)ccc(c1F)-c1cnc2[nH]c(=O)n(Cc3cccnc3)c2c1

InChI Key InChIKey=JHWJWHNLZXKLSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436958   

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM436958(US10617676, Example 293 | 6-(2,4-Difluoro-3-methyl...)
Affinity DataIC50: 17nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM436958(US10617676, Example 293 | 6-(2,4-Difluoro-3-methyl...)
Affinity DataIC50: 17nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
Go to US Patent