BDBM4367 (3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methylidene]prop-1-ene-1,1,3-tricarbonitrile::CHEMBL78257::benzylidenemalononitrile (BMN) deriv. 51

SMILES Oc1cc(C=C(C#N)C(=N)C(C#N)C#N)cc(O)c1O

InChI Key InChIKey=OPRGVJUSIWAHDE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 4367   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50: 800nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibitory activity against FGFR1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibitory activity against VEGFR2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory activity against PDGFRbeta kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibitory activity against EGFR kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50: 800nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4367((3Z)-2-amino-3-[(3,4,5-trihydroxyphenyl)methyliden...)
Affinity DataIC50: 800nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed