BDBM436669 US10610125, Example Table 24a.4

SMILES Cc1cc(ccc1-c1ccc(\C=C2\NC(=O)N(Cc3ccc(Br)cc3)C2=O)o1)C(O)=O

InChI Key InChIKey=ZNFDCAHAOQNVGS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 436669   

TargetL-lactate dehydrogenase A chain(Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436669(US10610125, Example Table 24a.4)
Affinity DataIC50: 3.38E+4nMAssay Description:All reactions were performed in standard enzyme reaction buffer (150 mM NaCl, 20 mM Tris-Cl, pH 7.5, 10% glycerol, 5 mM MgCl2 and 0.03% (w/v) bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
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TargetL-lactate dehydrogenase B chain(Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436669(US10610125, Example Table 24a.4)
Affinity DataIC50: 1.00E+5nMAssay Description:All reactions were performed in standard enzyme reaction buffer (150 mM NaCl, 20 mM Tris-Cl, pH 7.5, 10% glycerol, 5 mM MgCl2 and 0.03% (w/v) bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436669(US10610125, Example Table 24a.4)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays were conducted in a volume of 76 ul assay buffer (150 mM NaCl, 10 mM MgCl2, 20 mM Tris pH 7.5, 0.03% bovine serum albumin) as follows in a sta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436669(US10610125, Example Table 24a.4)
Affinity DataIC50: 1.92E+4nMAssay Description:Assays were conducted in a volume of 76 ul assay buffer (150 mM NaCl, 10 mM MgCl2, 20 mM Tris pH 7.5, 0.03% bovine serum albumin) as follows in a sta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436669(US10610125, Example Table 24a.4)
Affinity DataIC50: 4.68E+4nMAssay Description:All reactions were performed in standard enzyme reaction buffer (150 mM NaCl, 20 mM Tris-Cl, pH 7.5, 10% glycerol, 5 mM MgCl2 and 0.03% (w/v) bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent