BDBM436667 US10610125, Example Table 24a.2

SMILES Cc1ccc(cc1)C1=NN(C(C1)c1cn(CCC(O)=O)nc1-c1ccccc1)c1ccccc1

InChI Key InChIKey=WLFJKBNDGHVXMT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 436667   

TargetL-lactate dehydrogenase A chain(Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436667(US10610125, Example Table 24a.2)
Affinity DataIC50: 5.92E+3nMAssay Description:All reactions were performed in standard enzyme reaction buffer (150 mM NaCl, 20 mM Tris-Cl, pH 7.5, 10% glycerol, 5 mM MgCl2 and 0.03% (w/v) bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
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TargetL-lactate dehydrogenase B chain(Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436667(US10610125, Example Table 24a.2)
Affinity DataIC50: 1.74E+4nMAssay Description:All reactions were performed in standard enzyme reaction buffer (150 mM NaCl, 20 mM Tris-Cl, pH 7.5, 10% glycerol, 5 mM MgCl2 and 0.03% (w/v) bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436667(US10610125, Example Table 24a.2)
Affinity DataIC50: 1.23E+4nMAssay Description:Assays were conducted in a volume of 76 ul assay buffer (150 mM NaCl, 10 mM MgCl2, 20 mM Tris pH 7.5, 0.03% bovine serum albumin) as follows in a sta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM436667(US10610125, Example Table 24a.2)
Affinity DataIC50: 4.14E+4nMAssay Description:Assays were conducted in a volume of 76 ul assay buffer (150 mM NaCl, 10 mM MgCl2, 20 mM Tris pH 7.5, 0.03% bovine serum albumin) as follows in a sta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent