BDBM436275 2,2-difluoro-3- ((6S,8R)-1- fluoro-6-(5- ((1-(3- fluoropropyl)aze- tidin-3- yl)amino)pyridin- 2-yl)-8- methyl- 3,6,8,9- tetrahydro-7H- pyrazolo[4,3- f]isoquinolin- 7-yl)propan-1- ol::US10590130, Example 61

SMILES C[C@@H]1Cc2c(ccc3[nH]nc(F)c23)[C@H](N1CC(F)(F)CO)c1ccc(OC2CN(CCCF)C2)cn1

InChI Key InChIKey=CJGQDXFVDSVQFT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436275   

LigandPNGBDBM436275(US10590130, Example 61 | 2,2-difluoro-3- ((6S,8R)-...)
Affinity DataIC50: 0.880nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandPNGBDBM436275(US10590130, Example 61 | 2,2-difluoro-3- ((6S,8R)-...)
Affinity DataIC50: 4.00E+4nMAssay Description:ER: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent