BDBM436197 US10590109, Compound 15::US10590109, Compound 20

SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N

InChI Key InChIKey=WMIQOTMTEKRJFD-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 436197   

TargetFibroblast growth factor receptor 4 [460-802](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 55nMAssay Description:FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1 [308-731](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 1.00E+3nMAssay Description:FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4 [460-802](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 10nMAssay Description:FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1 [308-731](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 1.00E+3nMAssay Description:FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2 [400-821](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 1.00E+3nMAssay Description:FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3 [399-806](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 1.00E+3nMAssay Description:FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG channel in presence of dofetilide by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 66nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM436197(US10590109, Compound 20 | US10590109, Compound 15)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed