BDBM436112 US10590105, Example 1006

SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN[C@](C)(CO)C(O)=O)cc2Cl)cccc1-c1cnc2ccccc2n1

InChI Key InChIKey=KJGBSKXWCFJEDI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436112   

TargetProgrammed cell death protein 1(Human)
Bristol-Meyers Squibb

US Patent
LigandPNGBDBM436112(US10590105, Example 1006)
Affinity DataIC50: 118nMAssay Description:The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM436112(US10590105, Example 1006)
Affinity DataIC50: 1nMAssay Description:Binding affinity to human PDL1 assessed as reduction in PDL1/human PD1protein-protein interaction by HTRF binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed