BDBM436047 2-(2,5-difluorophenyl)-1- ((1S,3R)-3-(hydroxymethyl)-1- methyl-5-(1H-pyrazol-4-yl)- 3,4-dihydroisoquinolin-2(1H)- yl)ethan-1-one::US10611751, Example 15

SMILES C[C@@H]1N([C@@H](CO)Cc2c1cccc2-c1cn[nH]c1)C(=O)Cc1cc(F)ccc1F

InChI Key InChIKey=JTRGJNLZRCHRRK-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436047   

TargetD(1A) dopamine receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM436047(US10611751, Example 15 | 2-(2,5-difluorophenyl)-1-...)
Affinity DataEC50:  836nMAssay Description:The PAM activity of the compounds of the present invention may be measured essentially as described in Svensson et al., An Allosteric Potentiator of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent