BDBM435791 1-((1S,3R)-5-(1-(2-(l1- oxidaneyl)ethyl)-1H-pyrazol- 4-yl)-3-(hydroxymethyl)-1- methyl-3,4- dihydroisoquinolin-2(1H)-yl)- 2-(2-chlorophenyl)ethan-1-one::US10611751, Example 5

SMILES C[C@@H]1N([C@@H](CO)Cc2c1cccc2-c1cnn(CCO)c1)C(=O)Cc1ccccc1Cl

InChI Key InChIKey=XEWHEGXLPGSDGJ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435791   

TargetD(1A) dopamine receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM435791(US10611751, Example 5 | 1-((1S,3R)-5-(1-(2-(l1- ox...)
Affinity DataEC50:  18.3nMAssay Description:The PAM activity of the compounds of the present invention may be measured essentially as described in Svensson et al., An Allosteric Potentiator of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent