BDBM435720 US10570155, Compound 8III::US11332479, Compound 8III

SMILES COc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCNS(=O)(=O)c2ccc(cc2)C(F)(F)F)n1

InChI Key InChIKey=ZDXCHNZCVKMKQZ-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 435720   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of ERN1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 9.25E+3nMAssay Description:Inhibition of NTRK2 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 20(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 8.11E+3nMAssay Description:Inhibition of ZAK (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 98nMAssay Description:Inhibition of MAPK14 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 120nMAssay Description:Inhibition of MAPK11 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 420nMAssay Description:Inhibition of MAPK8 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of HIPK1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 1.56E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 687nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 9.85E+3nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 142nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 687nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 98nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 687nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435720(US10570155, Compound 8III | US11332479, Compound 8...)
Affinity DataIC50: 98nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent