BDBM435659 (2R,3S,4R,5R)-2-((R)-(4-chloro-3- methylphenyl)(hydroxy)methyl)-3- methyl-5-(4-methyl-7H-pyrrolo[2,3- d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol::US10570140, Example 57::US11078205, Example 57::US11208416, Example 57

SMILES Cc1cc(ccc1Cl)[C@@H](O)[C@H]1O[C@H]([C@H](O)[C@]1(C)O)n1ccc2c(C)ncnc12

InChI Key InChIKey=LMQXLKNSRLIXHZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435659   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435659(US10570140, Example 57 | (2R,3S,4R,5R)-2-((R)-(4-c...)
Affinity DataIC50: 11nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435659(US10570140, Example 57 | (2R,3S,4R,5R)-2-((R)-(4-c...)
Affinity DataIC50: 11nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435659(US10570140, Example 57 | (2R,3S,4R,5R)-2-((R)-(4-c...)
Affinity DataIC50: 11nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent