BDBM435651 (2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimidin-7-yl)-2-((R)-(3,4- dichlorophenyl)(hydroxy)methyl)-3- methyltetrahydrofuran-3,4-diol::US10570140, Example 47::US11078205, Example 47::US11208416, Example 47

SMILES C[C@@]1([C@H]([C@@H](O[C@@H]1[C@@H](c2ccc(c(c2)Cl)Cl)O)n3ccc4c3ncnc4N)O)O

InChI Key InChIKey=NVZVVFMXEHOMQR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435651   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435651(US10570140, Example 47 | (2R,3S,4R,5R)-5-(4-amino-...)
Affinity DataIC50: 1.5nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435651(US10570140, Example 47 | (2R,3S,4R,5R)-5-(4-amino-...)
Affinity DataIC50: 1.5nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435651(US10570140, Example 47 | (2R,3S,4R,5R)-5-(4-amino-...)
Affinity DataIC50: 1.5nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent