BDBM435632 US10570121, Example 138::US10570121, Example 139

SMILES COC(C1CN(C1)C(=O)CO)c1cc(Br)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=PPJPTEVMFGGNPK-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 435632   

LigandPNGBDBM435632(US10570121, Example 139 | US10570121, Example 138)
Affinity DataIC50: 249nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

LigandPNGBDBM435632(US10570121, Example 139 | US10570121, Example 138)
Affinity DataIC50: 8.5nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM435632(US10570121, Example 139 | US10570121, Example 138)
Affinity DataKi:  0.5nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM435632(US10570121, Example 139 | US10570121, Example 138)
Affinity DataKi:  46nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent