BDBM435630 (Z)-7-((2R,3R,4S,5R)-3,4-dihydroxy-5- (((2-(methoxyamino)quinolin-7- yl)oxy)methyl)-4-methyltetrahydrofuran- 2-yl)-3,7-dihydro-4H-pyrrolo[2,3- d]pyrimidin-4-one O-methyl oxime::US10570140, Example 45::US11078205, Example 45::US11208416, Example 45

SMILES CONc1ccc2ccc(OC[C@H]3O[C@H]([C@H](O)[C@]3(C)O)n3ccc4c3nc[nH]\c4=N/OC)cc2n1

InChI Key InChIKey=KJPJWKFOPWVXEL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435630   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435630(US10570140, Example 45 | (Z)-7-((2R,3R,4S,5R)-3,4-...)
Affinity DataIC50: 1.15E+4nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435630(US10570140, Example 45 | (Z)-7-((2R,3R,4S,5R)-3,4-...)
Affinity DataIC50: 1.15E+4nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435630(US10570140, Example 45 | (Z)-7-((2R,3R,4S,5R)-3,4-...)
Affinity DataIC50: 1.15E+4nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent