BDBM435608 (2S,3S,4R,5R)-N-(3- (aminomethyl)phenyl)-5-(4-chloro-7H- pyrrolo[2,3-d]pyrimidin-7-yl)-3,4- dihydroxy-3-methyltetrahydrofuran-2- carboxamide::US10570140, Example 42::US11078205, Example 42::US11208416, Example 43

SMILES C[C@]1(O)[C@@H](O)[C@@H](O[C@@H]1C(=O)Nc1cccc(CN)c1)n1ccc2c(Cl)ncnc12

InChI Key InChIKey=FWCLXDKNWVVBOW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 435608   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435608(US10570140, Example 42 | (2S,3S,4R,5R)-N-(3- (amin...)
Affinity DataIC50: 9.10E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435608(US10570140, Example 42 | (2S,3S,4R,5R)-N-(3- (amin...)
Affinity DataIC50: 9.10E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435608(US10570140, Example 42 | (2S,3S,4R,5R)-N-(3- (amin...)
Affinity DataIC50: 9.10E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435608(US10570140, Example 42 | (2S,3S,4R,5R)-N-(3- (amin...)
Affinity DataIC50: 825nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent