BDBM435601 (2S,3S,4R,5R)-3-methyl-5-(4- (methylamino)-7H-pyrrolo[2,3- d]pyrimidin-7-yl)-2- ((methylthio)methyl)tetrahydrofuran- 3,4-diol::US10570140, Example 40::US11078205, Example 40::US11208416, Example 40

SMILES CNc1ncnc2n(ccc12)[C@@H]1O[C@H](CSC)[C@@](C)(O)[C@H]1O

InChI Key InChIKey=MLIJDSYMNNILFK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435601   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435601(US10570140, Example 40 | (2S,3S,4R,5R)-3-methyl-5-...)
Affinity DataIC50: 1.41E+4nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435601(US10570140, Example 40 | (2S,3S,4R,5R)-3-methyl-5-...)
Affinity DataIC50: 1.41E+4nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435601(US10570140, Example 40 | (2S,3S,4R,5R)-3-methyl-5-...)
Affinity DataIC50: 1.41E+4nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent