BDBM435289 N-(tert-butyl)-5-(3-(2-hydroxypropan- 2-yl)phenyl)-8-(((trans)-2- phenylcyclopropanecarboxamido) methyl)-3,4-dihydroisoquinoline-2(1H)- carboxamide (mixture of 2 isomers)::US10568876, Example 52

SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cccc(c1)C(C)(C)O

InChI Key InChIKey=CZHICPHWKMJBAT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435289   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435289(US10568876, Example 52 | N-(tert-butyl)-5-(3-(2-hy...)
Affinity DataIC50: 20.2nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
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Date in BDB:
11/30/2020
Entry Details
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