BDBM435244 N-(tert-butyl)-8-(((trans)-2- phenylcyclopropanecarboxamido) methyl)-5-(3-(trifluoromethoxy)phenyl)- 3,4-dihydroisoquinoline-2(1H)- carboxamide (mixture of 2 isomers)::US10568876, Example 9

SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)[C@H]1C[C@@H]1c1ccccc1)ccc2-c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=CVFQSYQBHGKGSN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435244   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435244(US10568876, Example 9 | N-(tert-butyl)-8-(((trans)...)
Affinity DataIC50: 31nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
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